Postdoctoral/Research Faculty Positions in Solution NMR Structural
Biology of Large Modular Proteins
Laboratory of Walter Chazin,
Center for Structural Biology, Vanderbilt University
(1) Regulation of human cardiac Na+ channels and
origin of cardiac arrhythmias
(2) Multi-protein DNA replication, damage response and
repair machinery
These positions provide excellent opportunities to
both hone NMR skills on exciting high profile protein systems while
also providing opportunities to learn new structural biology techniques
including X-ray scattering, X-ray crystallography and computational
modeling. Both research programs incorporate multi-disciplinary
biological and medical studies and routinely produce publications in a
range of high profile journals.
Project 1 is directed to understanding the
structural basis for calcium dependent regulation of gating of the
human cardiac sodium channel Nav1.5, and the origin of cardiac
arrhythmias in patients with mutations in the regulatory
apparatus. Project 2 involves studies of the structure and
dynamics of large multi-domain proteins (e.g. replication protein A,
DNA primase, XPC) and protein and DNA complexes within DNA replication,
damage response and repair machines.
The Vanderbilt Center for Structural Biology has
outstanding instrumentation in all areas, including a soon to be
installed 900 as well as 800, 600 and 500 MHz NMR spectrometers
equipped with cryoprobes. Applicants are expected to work well
with graduate students and will be encouraged to develop their
leadership potential. Send CV and a reference list via e-mail
to: walter.chazin@vanderbilt.edu.
Vanderbilt University
is an equal opportunity employer.
