Postdoctoral Position to study Protein-Protein Interactions using
Molecular Modeling, Docking and Dynamics Simulations
Case Western Reserve Univ.,
Medical School Cleveland, Ohio, USA
How
are signaling events transmitted from one protein to another?
To answer this question we are looking to add a postdoctoral co-worker
to our interdisciplinary team in order to help us with computational
aspects of a number of projects. Our interest is to understand
protein-protein interactions, protein structure and dynamics in the
context of cell signaling mechanisms. {e.g. J.Biol.Chem.,282,
37215-37224 (2007), Structure 16, 246-258 (2008), J.Mol.Biol. 377,
1474-87 (2008), Protein Science(2009) online 3/18}. The systems include
several small GTPases and their interacting proteins, principally the
cytoplasmic domains of plexins and of other receptors.
Computational research in protein
biophysics/structural biology. The project will involve
structure refinement calculations using NMR derived restraints
(xplor-NIH and HADDOCK), docking calculations (ROSETTADOCK) as well as
free energy type calculations (e.g. FoldX). In addition we carry out
classical as well as accelerated molecular dynamics simulations using
CHARMM/NAMD. There is also the possibility for method development of a
primary hydration shell model (e.g. see Biophys. J. 2007, 92, L49-51;
J. Comp. Chem. 2009, online ~5/6/09).
We are looking for a talented and
motivated coworker, who aims to become an independent
researcher/project leader. Background in molecular modeling and/or
simulations is required, interest in NMR and protein dynamics is a big
plus. Experience with python, Fortran/C programming is recommended, as
is a strong desire to learn about protein-protein interactions and
protein biophysics. The Buck laboratory provides a stimulating
but friendly working environment – we are still relatively small &
young, which has advantages. The Medical School of Case Western Reserve
University is highly rated overall in the US (~ 13th in terms of NIH
funding) and Cleveland is a pleasant but affordable place to live with
excellent educational, medical and cultural institutions. Starting date as soon as possible; salary
is NIH scale. Please check out our lab. page for further details
at http://mbalster.case.edu/;
if interested, please send your resume, overview of your scientific
interests and career goals as well as contact details of three referees
able to provide references by e-mail to Matthias.Buck@case.edu
