Postdoctoral Position -- Computational Modeling and NMR Structural
Studies of pH Sensor Proteins Involved in Cell Mobility
Department of Pharmaceutical
Chemistry
University of California San Francisco
A
postdoctoral position is available in the groups of Matt Jacobson and
Mark Kelly in the Department of Pharmaceutical Chemistry at UCSF
(Mission Bay Campus) to investigate how small changes in pH affect the
conformations and dynamics of proteins regulating the actin
cytoskeleton and cell mobility (Srivastava et al., 2008 PNAS
105:14436-41; Frantz et al., J Cell Biol. 183:865-79). In
collaboration with Diane Barbers’ group these studies will bridge cell
signaling, cell biology, and computational and experimental biophysics
to determine at the molecular level the regulation and function of pH
sensors in cell polarity, actin-dependent membrane protrusion, and cell
adhesion. Investigations will involve applying physics-based
predictive protein modeling and NMR investigations of conformational
and dynamic changes in regulatory proteins. The position is ideal
for applicants who have a strong background in biophysics, chemistry or
related field and experience of either computational structural
biophysics or NMR, and wish to broaden their expertise. The UCSF
Mission Bay campus offers an excellent scientific environment for
computational and structural biology (computing clusters, 500, 600 and
800 MHz spectrometers with cryogenic probes, and access to a 900 MHz
instrument).
Applications should be addressed to or for further information please
contact:
Matt Jacobson Ph.D.
UCSF MC 2240
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. 415-514-9811
matt.jacobson@ucsf.edu
http://www.jacobsonlab.org/
or
Mark Kelly Ph.D.
UCSF, MC 2280
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. (415)-476-8143
Mark.Kelly@ucsf.edu
