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SpinCore Technologies, Inc.
4623 NW 53rd Avenue, Suite 5
Gainesville, Florida 32653, USA
| GENEERAL
INTEREST and CURRENT ACTIVITIES: |
General Field: Embedded
electronics research and instrumentation development for Magnetic
Resonance (NMR, MRI, QR), mass spectrometery, ultrasound, spintronics,
photonics research, and related resonance and test technologies.
General Technology and
Activity: Systems-on-chip integration and
Programmable-logic implementations.
General Role: Executive
Management.
| RESEARCH
AND TEACHING INTERESTS WHILE AT THE UNIVERSITY OF FLORIDA: |
General Area: Magnetic Resonance (NMR)
- Technological Developments
- Interdisciplinary Applications
- Graduate and Undergraduate NMR Laboratory Education.
Specific Activities (in collaboration with faculty
and
students
accross departments, colleges, and institutions).:
Cancer Research
- Inhibitory role of metal ions in malignal cell growth;
- Therapy-response markers by in vivo and in-situ (in-vitro)
NMR spectroscopy.
Molecular Physics, Chemistry and Microbiology:
- Microbial and cellular metabolism by in-vivo and in-vitro
NMR spectroscopy;
- Structural analysis of complex biological polymers, toxic biological
substances, and metabolites;
- Bioinformatics and genomic analysis;
- Molecular and lattice dynamics, polymorphism and phase transitions
in disordered systems studied by NMR spin relaxation and NMR line
analysis.
Nuclear Magnetic Resonance (NMR) methods:
- High-resolution, solution NMR of perfused cells: in-situ,
in-vitro,
and in-vivo NMR spectroscopy;
- High resolution NMR of solids: magic-angle-spinning (MAS) and
combined
rotation and multiple pulse spectroscopy (CRAMPS);
- NMR imaging and microimaging; chemical shift imaging in the solid
state.
Electronics and Electrical Engineering:
- VHDL and ASIC design strategies;
- Integrated systems development - complex scientific and medical
instruments;
- Pulse and digital techniques, broadband systems, transient response
and signal-to-noise optimization;
- Temperature probeheads;
- Magnetic-field gradient coil systems for NMR and MRI imaging.
Computer and Information Sciences:
- Global optimization by simulated annealing;
- Client-server computing and distributed systems;
- Internet Applications - remote control of scientific instruments;
- NMR quantum computing - instrumentation development;
- Local-Area network implementations, platforms' integration and UNIX
administration.
Courses Taught
MCB 5303L -
Microbial Genetics (NMR Laboratory Instruction).
PCB
5136L - Techniques in Microbial & Cell Biology (NMR Laboratory
Instruction).
MCB
6937 - Special Topics in Microbiology (Selected problems and
projects).
EEL 5905 - Individual Work (Selected problems
and projects).
2004
Johnson CL, Buszko ML, Bobik TA.: Purification
and initial characterization of the Salmonella enterica PduO
ATP:Cob(I)alamin adenosyltransferase, J Bacteriol. 2004
Dec;186(23):7881-7.
Underwood S. A, Buszko M. L,
Shanmugam K.T, Ingram L.O.: Lack of
protective
osmolytes limits final cell density and volumetric productivity of
ethanologenic
Escherichia coli KO11 during xylose fermentation. Appl Environ
Microbiol.
2004 May;70(5):2734-40.
Gutierrez T, Buszko ML, Ingram LO, Preston JF.:
Reduction of furfural
to
furfuryl alcohol by ethanologenic strains of bacteria and its effect on
ethanol production from xylose. Appl Biochem Biotechnol. 2002
Spring;98-100:327-40.
Underwood SA, Buszko ML, Shanmugam KT, Ingram LO.,
Flux
through citrate
synthase limits the growth of ethanologenic Escherichia coli KO11
during
xylose fermentation. Appl Environ Microbiol. 2002
Mar;68(3):1071-81.
Healy, F. G., Buszko, M. L., Tao, H., Gonzales,
R., and Shanmugam,
K.T.,
and Ingram, L.O.: Altered sugar utilization patterns by Escherichia
coli
carrying plasmid-encoded xylose operons wiht cAMP/XylR-independent
promoters.
101th General Meeting of the American Society for Microbiology,
Orlando,
Florida, USA.
Park YI, Buszko ML, Gander JE.: Glycine
betaine: reserve form of
choline
in Penicillium fellutanum in low-sulfate medium. Appl Environ
Microbiol.
1999 Mar;65(3):1340-2.
1998
W. Pawlina, M.L. Buszko, R. A. Zaldivar and S.C.
Frost: In
Vivo Study of Glycogen Metabolism in 3T3-L1 Adipocytes Under Perfusion
by 13C-NMR Spectroscopy, (1998)
Marian
L. Buszko, Daniel C. Wang, and Dominik Buszko: A
Common Gateway
Interface Program for the World-Wide Web NMR Spectrometer, Journal of
Magnetic
Resonance 131, 362-366 (1998).
M.L.
Buszko and D.C. Wang: A
World-Wide Web Interface to an NMR Spectrometer. Applied Magnetic
Resonance
12, 95-101 (1997).
Buszko
ML, Kempka MF, Szczesniak E, Wang DC, Andrew ER: Optimization
of Transverse Gradient Coils with Coaxial Return Paths by Simulated
Annealing. Journal
of Magnetic Resonance, series B, 112(3):207-213, Sep 1996.
Marian
L. Buszko and Gary E. Maciel: Solid-State 1H
CRAMPS
NMR Imaging with Pulsed Rotating Magnetic Field Gradients; J. Magn.
Reson.
A110, 1 (1994.)
Marian
Buszko and Gary Maciel: Proton Spectroscopic Imaging
in the Solid
State by TREV-CRAMPS" ; J. Magn. Reson. A110, 7 (1994).
Marian
Buszko and Gary E. Maciel Magnetic-Field-Gradient
Coil System for Solid-State MAS and CRAMPS NMR Imaging;J. Magn.
Reson.
A107, 151 (1994).
Moye, Gander, Brey, Buszko: Formation of
N,N'-Dibutylurea from n-Butylisocyanate, a
Degradation
Product of Benomyl; J. Ag. and Food Chem. 42, 1204 (1994).
Y. Park, M.L. Buszko, and J.E. Gander: Fungal
Glycopeptides and Regulation of
exo-beta-D-Galacto-furanosidase
Activity; Proceedings of '94 Agricultural Biotechnology Symposium on
Enzymes
for Carbohydrate Engineering, pp 135-159, August 26, 1994, Suwon, S.
Korea.
Buszko
ML, Andrew ER.: 1H NMR study of lithium
D-lactate.
Solid State Nucl Magn Reson. 1992 Jul;1(3):115-9.
Currently: SpinCore Technologies, Inc. - Chief Executive
Formerly: IFAS NMR
Facility
- Director
Formerly: Department of Microbiology and Cell Science Information
Technologies
- Director
“Zinc and Prolactin Regulation of Prostate Cancer Cell Energy
Metabolism,” American Institute for Cancer Research, co-PI, 2001-2003,
$165,000.
“Application of Functional Genomics to Recombinant
Biocatalysts for
Fuel and Chemicals,” United States Department of Agriculture, co-PI,
2000-2003,
$2,000,000.
"Prostate Cancer: Inhibitory Role of Zinc in Malignant Cell
Growth,"
Opportunity Fund Award, University of Florida, co-PI, 1998-1999,
$66,000.
"World-Wide Web NMR Spectrometer: A Teaching Tool for
Undergraduate
Education," USDA Challenge Grant Program, PI, 1998-2001, $176,000
(total
cost, 50 % matched).
"A Magnetic Resonance Imaging Spectrometer as a Web
Appliance," Sun
Microsystems' Academic Equipment Grant Program, PI, 1998, $60,000 (in
kind).
"A Proposal to Acquire High Resolution Solids NMR Capability
at the
University of Florida," National Science Foundation's Major Research
Instrumentation
Program, participating scientist, 1997 (approx. $800,000 total cost).
"Minigrant Proposal for the Improvement of Instruction,"
Institute of
Food and Agricultural Sciences Dean for Academic Programs, PI, 1997,
$3,000.
"A World-Wide Web NMR Spectrometer" Institute of Food and
Agricultural
Sciences Dean for Instructions Award, PI, 1996, $10,000.
"Minister of Education Award for Ph.D. Thesis," Nominated by
the Dissertation
Committee, Adam Mickiewicz University, Poznan, Poland, 1987.
"The Most Useful M.Sc. Thesis," - The National Award of The
Ministry
of Higher Education and Association of Polish Students; 1st Prize, 1978.
American Association for the Advancement of Science
(AAAS);
American Chemical Society
(ACS);
International Society of Magnetic Resonance (ISMAR);
Sigma Xi.
2000-2005: North-East Regional Data Center (NERDC, currently CNS)
Instruction and
Research Committee,
University of Florida, Gainesville.
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